Investigating the Role of Slow-wave Activity as a Marker of Impaired Plasticity in Major Depressive Disorder

Investigating the Role of Slow-wave Activity as a Marker of Impaired Plasticity in Major Depressive Disorder

Investigating the Role of Slow-wave Activity as a Marker of Impaired Plasticity in Major Depressive Disorder

Recruiting
25-50 years
All
Phase N/A
If you agree to join the study, you will be asked to complete the following research procedures: You will first attend a 3 hour screening session. You and the study staff will discuss the study details and sign the consent form. You will then complete some questionnaires about your sleep, thoughts, and feelings. You will also have an interview that will include questions about your history of mental health symptoms. At this visit, you will also take a tour of lab where the TMS will take place. For 5 days prior to your in-lab stays, you will be asked to wear a wrist worn device which measures activity levels during the day and at night while completing a sleep diary each day. Visits 2 and 3 will be conducted at the Sleep Center located at the Hospital of the University of Pennsylvania.  You will be asked to arrive at the Sleep Center at 8pm. You will be asked to wear several sensors designed to measure sleep while also having an overnight sleep study. The following morning, you will have a blood sample taken, be provided with breakfast, complete computerized tasks and complete the TMS protocol. Afterwards you will be free to leave.  The second overnight will be the same as the first except auditory tones will be played throughout the night during SWS. In the morning you will follow the same procedures.
Your participation will last for approximately a month.

Study details
    Depression
    healthy controls

04150718

19 February 2024

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