A Phase 1 Open-Label Multi-Center First in Human Study of TnMUC1-Targeted Genetically-Modified Chimeric Antigen Receptor T Cells in Patients with Advanced TnMUC1-Positive Solid Tumors and Multiple Myeloma

  • STATUS
    Enrolling By Invitation
  • participants needed
    27
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Updated on 19 February 2024

Summary

Multi-center, open-label, first in human (FIH) Phase 1 study of the safety, tolerability, feasibility, and preliminary efficacy of the administration of genetically modified autologous T cells (CART-TnMUC1 cells) engineered to express a chimeric antigen receptor (CAR) capable of recognizing the tumor antigen, TnMUC1 and activating the T cell (CARTTnMUC1 cells). The Phase 1 portion of the trial is designed to identify a dose and regimen of CARTTnMUC1 cells that can be safely administered to patients with refractory malignancies. The single arm Phase 1a expansion portion of the trial includes patients with TnMUC1+ platinum-resistant ovarian cancer.

Details
Condition myeloma
Age 99years or below
Clinical Study Identifier04025216
Last Modified on19 February 2024

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