A randomized double-blind placebo-controlled parallel group study to evaluate the efficacy and safety of CNP520 in participants at risk for the onset of clinical symptoms of Alzheimers Disease (AD)

  • STATUS
    Recruiting
  • participants needed
    10
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Updated on 19 February 2024

Summary

The study will enroll cognitively unimpaired individuals who are between the ages of 60-75 years with at least one APOE4 allele (HMs or HTs) and, if HTs, with evidence of elevated brain amyloid. Cognitively unimpaired subjects defined as having a Mini-Mental State Examination (MMSE) total score greater than or equal to 24. Subjects must be willing to have a study partner throughout the study. Approximately 2000 participants will be randomized in approximately 135 centers worldwide. The study will be conducted with a randomization ratio 50mg:15mg:placebo of 2:1:2. Arm #1: CNP520 50 mg capsule for. p.o. administrationor CNP520 LDR if DRM is activated Arm #2: CNP520 15 mg capsule for p.o. administrationor CNP520 LDR if DRM is activated Arm #3: Placebo to CNP520 capsules for p.o. administration The investigation drug will be stored in a secured locked cabinet in the Penn Memory Clinic. .

Details
Condition Alzheimers Disease, ALZ, memory
Age 99years or below
Clinical Study Identifier03131453
Last Modified on19 February 2024

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