Towards predicting the analgesic response to ibuprofen following third-molar extraction

  • STATUS
    Recruiting
  • participants needed
    80
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Updated on 19 February 2024

Summary

NSAIDs like ibuprofen are pain relievers that are commonly used to reduce pain after dental procedures. 
Patients who have their impacted third molar teeth taken out usually experience pain one to three hours after surgery and require pain relievers for at least 2 days. Most people (about 70-90%) experience good to excellent relief of their pain when they take ibuprofen. However, some patients experience only limited pain relief with ibuprofen, and a few experience no pain relief at all. These patients need a different type of pain reliever added to their regimen. The purpose of this study is to see if there are substances in your blood and urine which we will take both before and after your wisdom teeth surgery that can tell us how you personally will respond to ibuprofen in comparison to placebo (an inactive sugar pill). We will also study how well ibuprofen combined with acetaminophen  works for up to 7 days after surgery.

Description

There are 4 study visits:
1) Screening - patients read and sign informed consent, urine and blood sample are taken, fill out questionnaire about mood and pain expectations.
2) Surgery - Swab of mouth to collect bacteria, urine and blood sample taken prior to surgery. Have surgery performed standard of care, receive study medication (ibuprofen 400 mg or placebo), multiple urine and blood samples (through indwelling catheter) taken, pain assessments taken, discharged with ibuprofen 400mg/acetaminophen500mg taken q4h and oxycodone 5mg if needed
3) 24 Hour Follow-up - Return visit with a single blood and urine sample
4) Day 7 Follow-up - Return visit with a single blood and urine sample

FAQ

If you are interested in participating in this study or would like more information, please complete the form below or call Stacey Secreto in the Oral Surgery and Pharmacology Research Unit at 215-746-8871.

Details
Condition Impacted Third Molar Tooth | Pain,Acute
Age 18years - 64years
Clinical Study IdentifierNCT03893175
Last Modified on19 February 2024

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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