A Phase 2 Multicenter Open-Label Extension Study to Evaluate the Safety and Tolerability of AK002 in Patients with Eosinophilic Gastritis and/or Eosinophilic Gastroenteritis

  • STATUS
    Enrolling By Invitation
  • participants needed
    6
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Updated on 19 February 2024

Summary

AK002 is a humanized non-fucosylated immunoglobulin G1 (IgG1) monoclonal antibody to the inhibitory receptor Siglec-8, present on mast cells, eosinophils, and basophils. Binding of AK002 to Siglec-8 induces a signal that inhibits mast cell activation and can lead to apoptosis in eosinophils. In the presence of effector cells (such as natural killer [NK] cells), AK002 binding to Siglec-8 depletes circulating eosinophils by ADCC and may reduce eosinophil and mast cell numbers in tissue. This profile of activity may provide clinical benefit in diseases in which these cell types play a role, such as EG and/or EGE.

Details
Condition Gastroenteritis
Age 99years or below
Clinical Study Identifier03664960
Last Modified on19 February 2024

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If you need help finding a study or have any questions, please contact us at psom-ocr@pobox.upenn.edu

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