A Phase 2 Randomized Placebo-Controlled Study of Safety and Efficacy Following Repeat-Dose Administration of Evinacumab (anti-ANGPTL3) in Patients with Severe Hypertriglyceridemia (sHTG) at Risk for Acute Pancreatitis

  • STATUS
    Recruiting
  • participants needed
    10
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Updated on 19 February 2024

Summary

A phase 2, randomized, placebo-controlled study designed to evaluate the efficacy and safety of repeated doses of evinacumab in adult patients with severe hypertriglyceridemia. The study consists of screening period (up to 37 days), a baseline/single-blind placebo run in period, a 12-week double-blind treatment period, a single-blind 12 week treatment period and an off-treatment follow-up period. Subjects will have the following procedures: blood work, LPL activity test, daily symptom questionnaire and a symptom/dietary impact questionnaire (hypertriglyceridemia and Acute Pancreatitis Signs and Symptoms), physical examiniation, ECG, MRI, and FDG-PET

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Condition TBD
Age 99years or below
Clinical Study Identifier03452228
Last Modified on19 February 2024

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