Mechanisms for Individual Differences in Hypertension in Obstructive Sleep Apnea

  • STATUS
    Recruiting
  • participants needed
    200
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Updated on 19 February 2024

Summary

The purpose of this study is to compare the response to PAP treatment of patients with Obstructive Sleep Apnea (OSA) who have normal blood pressure to those with treated (that is taking medication or on a special diet) high blood pressure.

Description

OSA is a breathing disorder during sleep. It is caused by a blockage of the airway, usually when the soft tissue in the back of the throat collapses during sleep. OSA is believed to cause high blood pressure, heart attacks, stroke, and problems with control of blood sugar.

Positive Airway Pressure (PAP) is a treatment in which a mask is worn over the nose and/or mouth while you sleep. The mask is hooked up to a machine that delivers a flow of air to the mask. The positive flow of air helps keep the throat open so that breathing is not impaired. 

We are enrolling patients with OSA who have either treated high blood pressure, uncontrolled high blood pressure, or normal blood pressure. You will be scheduled to have a series of tests at the start of the study and after 4 months of PAP treatment.

This study will take up to 24 weeks for you to finish. The entire study may last for 4 years. A total of 200 adults with OSA will be asked to take part at the University of Pennsylvania.

FAQ

Compensation is provided.

Details
Condition hypertension,sleep,OSA,sleep apnea,apnea
Age 18years - 75years
Clinical Study Identifier823172
Last Modified on19 February 2024

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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