Chronic insomnia and CSF markers of dementia

  • STATUS
    Recruiting
  • participants needed
    30
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Updated on 19 February 2024

Summary

The purpose of this study is to identify the relationship between chronic sleep disturbance and chemicals in spinal fluid that are related to dementia and a molecule called orexin that helps regulate wakefulness and appetite in the brain. Individuals with sleep problems and good sleepers will be asked to participate.

Description

If you agree to participate your participation will involve two visits. Both visits will take place at the Center for Human Phenomic Science (CHPS; formerly the Clinical and Translational Research Center) at the Hospital of the University of Pennsylvania.  You will asked to wear an activity monitoring device called an actiwatch for one week at home. You will be asked to complete a sleep diary throughout the week. One evening, two technicians will come to your home to set you up with equipment to record your sleep overnight. 


For your second visit you will come to the CHPS at 5:00 pm and be checked into the hospital. During the rest of the evening you will be free to engage in activities of your own choosing including watching TV, reading, or talking on your personal phone. During the night you are in the CHPS, your sleep will be monitored. 

At 8 am, a neurologist experienced with this procedure will conduct a neurological exam prior to performing a lumbar puncture (“spinal tap”) to collect your cerebrospinal fluid (“CSF”). The exam will be used to determine if you have any medical conditions that would increase the risk of the lumbar puncture.
 
 

FAQ

You will be compensated $25 for completion of the screening visit and $300 for the 22 hours spent in the hospital, for a total of $325 if you complete the entire study.Payment will be received via Clincard which is a web-based, reloadable, debit card used for people participating in research.

Details
Condition dementia,insomnia
Age 30years - 50years
Clinical Study Identifier829221
Last Modified on19 February 2024

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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