Dapagliflozin Effect on symptoms and blomarkers in patients with Heart Failure (DEFINE-HF)

  • STATUS
    Recruiting
  • participants needed
    30
  • sponsor
    Saint Luke's Hospital of Kansas City is sponsoring this study from funding provided by AstraZeneca Pharmaceuticals LP
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Updated on 19 February 2024

Summary

The purpose of this study is to find out if a drug called dapagliflozin would be effective in improving the blood tests and symptoms related to your heart failure.

Description

Dapagliflozin lowers glucose (sugar) levels in the blood by blocking the effect of specific molecules (small particles) in your body called sodium-glucose transporters. Under normal circumstances, the sodium-glucose transporters in the kidney prevent glucose in your blood stream from leaving your body through your urine. Dapagliflozin inhibits the sodium-glucose transporters and lowers your blood glucose by allowing glucose removal through the urine. Dapagliflozin may also mildly decrease body weight and lower blood pressure in certain patients. In this study, dapagliflozin will be compared with placebo. The placebo will look like dapagliflozin but is inactive. Patients will be randomly chosen to receive either dapagliflozin or placebo and neither the physician nor the patient will know which they are receiving until the entire study is completed. Patients will continue to take to take their regular diabetes medications, unless their diabetes is very well controlled in which case their dose of insulin or oral diabetes medication may be decreased.

FAQ


Details
Condition heart failure
Age 18years - 100years
Clinical Study IdentifierTBD.
SponsorSaint Luke's Hospital of Kansas City is sponsoring this study from funding provided by AstraZeneca Pharmaceuticals LP
Last Modified on19 February 2024

Eligibility

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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