Acute and Long-term Effects of E-Cigarette Aerosol Inhalation on Biomarkers of Endothelial Function and Vascular Reactivity

  • STATUS
    Recruiting
  • participants needed
    129
Send
Updated on 19 February 2024

Summary

The purpose of this study is 1) to examine the acute effects of nicotine free e-cigarette aerosol on vascular function in healthy, non-smokers and 2) to examine and compare vascular function in healthy smokers chronically exposed, at baseline and after 12 months, to nicotinized e-cigarette aerosol versus conventional cigarettes as compared to age, gender and body mass index-matched nonsmokers. Each participant, from both cohorts, will undergo 2 MRIs and 2 blood draws, per visit. All participants will be compensated for time taken to participate in the study. Key eligibility criteria include men and women, ages 18-35 with a BMI of 18.5-30. No contradictions with MRI.

Description

Non-smokers: these participants will complete 1 study visit. The study visit will consist of 2 blood draws, 2 MRIs and 1 smoking encounter of a non-nicotine e-cigarette. These visits last around 3-3.5 hours. Smokers: these participants will complete 2 study visits. Of the smokers, there are 2 cohorts of interest: conventional and e-cigarette smokers. The baseline and 12 month visits will consist of 1 blood draw and one MRI. Each visit will last about 1.5 hours. Prior to enrollment, subjects will be asked to undergo a brief telephone screening to confirm eligibility. This will be done with either study coordinator, Alyssa Johncola or Kelly Sexton.

Details
Condition healthy Volunteers, smokers, healthy subjects, Healthy, healthy controls, Smoking, Healthy volunteer, healthy, healthy volunteer, healthy volunteers, healthy subjects, healthy, healthy controls, healthy controls, smoker, e-cig, e-cigarette
Age 18years - 35years
Clinical Study IdentifierNCT03479203
Last Modified on19 February 2024

Eligibility

How to participate?

Step 1 Connect with a study center
Message sent successfully.
We have submitted the information you provided to the research team at the location you chose. For your records, we have sent a copy of the message to your email address.
If you would like to be informed of other studies that may be of interest to you, you may sign up for Patient Notification Service.
Sign up

Send a message

Enter your contact details to connect with study team

Email

View email

Phone

Phone country flag

View phone
Investigator Avatar

Primary Contact

First name*
Last name*
Email*
Phone number*
Preferred way of contact
Race
Ethnicity
Other language

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.