Cerebrovascular reactivity assessed with functional near-infrared spectroscopy as a biomarker of traumatic microvascular injury after traumatic brain injury

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    Enrolling By Invitation
  • participants needed
    170
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Updated on 19 February 2024

Summary

Traumatic cerebrovascular injury (TCVI) is common after traumatic brain injury (TBI) and an attractive target for therapeutic intervention. We will longitudinally measure cerebrovascular reactivity (CVR) by functional near-infrared spectroscopy (fNIRS) in acute (3 days from injury), subacute, and chronic phases after TBI as a biomarker of TCVI as compared to healthy controls. CVR will be measured by fNIRS response to hypercapnia. We hypothesize that CVR will be decreased after TBI and that these decreases will correlate with clinical outcomes. Furthermore, we predict that administration of a vasodilatory medication (sildenafil) will augment CVR after TBI.

Details
Condition TBI
Age 99years or below
Clinical Study Identifier99999999
Last Modified on19 February 2024

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