Trauma Induced Coagulapathy and Inflammation

  • STATUS
    Recruiting
  • participants needed
    300
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Updated on 19 February 2024

Summary

While a number of factors are known to be associated with the development of trauma induced coagulopathy (TIC), inflammation, and multi-organ failure, we currently cannot predict which patients are at risk for developing these life-threatening conditions with any certainty. In this prospective observational study, we will investigate the many factors that contribute to the development of trauma induced coagulopathy, post injury inflammation and the development of organ dysfunction in order to develop a multi scale computational algorhythm and ex vivo models capable of clinical prediction. Using a convenience sample technique, demographic data, physiologic data, fresh and residual blood samples, urine samples, and clinical variables will be collected over 5 days following traumatic injury. In addition to a computational model, ex vivo models using microfluidic devices and high resolution cellular respirometry, and nucleic acid analysis will be used to predict the development of TIC and multi-organ failure.

Details
Condition Trauma Injury | Trauma | Coagulopathy
Age 99years or below
Clinical Study IdentifierN/A
Last Modified on19 February 2024

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