FES PET/CT in Endocrine Refractory Breast Cancer

  • STATUS
    Recruiting
  • participants needed
    85
Send
Updated on 19 February 2024

Summary

Patients with recurrent or metastatic ER+ breast cancer, who have failed prior endocrine therapy may be eligible for this study.  Patients may participate in this study, if they are at least 18 years of age, most participants will be receiving care at the clinical practices of the University of Pennsylvania.
 
Positron emission tomography (PET/CT) imaging will be used to evaluate estrogen receptor (ER) activity, in sites of metastatic disease, using the investigational radiotracer [18F]fluoroestradiol (FES).  Imaging will occur prior to starting new therapy.  Some patients may also undergo a second FES PET/CT scan, at the time of suspected progression of disease to compare for changes in FES uptake measures.
 
Patients may undergo primary tumor or metastatic biopsy, as part of their clinical care.  Patients may also be enrolled in a separate breast cancer biopsy protocol entitled “Metastatic Markers of Recurrent Tumor Phenotype for Breast Cancer” (METAMORPH).  We will ask permission to access tissue collected as part of clinical biopsy or METAMORPH, if available.  If the patient gives permission, archived tissue may be accessed for the purposes of this study to perform additional experimental pathology assays.

Description



Details
Condition Cancer,Breast Cancer,Metastatic Breast Cancer,Recurrent Breast Cancer,ER+ Breast Cancer
Age 18years - 99years
Clinical Study Identifier02409316
Last Modified on19 February 2024

Eligibility

How to participate?

Step 1 Connect with a study center
Message sent successfully.
We have submitted the information you provided to the research team at the location you chose. For your records, we have sent a copy of the message to your email address.
If you would like to be informed of other studies that may be of interest to you, you may sign up for Patient Notification Service.
Sign up

Send a message

Enter your contact details to connect with study team

Email

View email

Phone

Phone country flag

View phone
Investigator Avatar

Primary Contact

First name*
Last name*
Email*
Phone number*
Preferred way of contact
Race
Ethnicity
Other language

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.