Evaluation of OCT-Angiography in Retinal and Optic Neuropathy Patients

To evaluate the correlation in various retinal diseases between the FD-OCT (Optical Coherence Tomography device) eye images acquired using the AngioVue based on RTVue XR platform (the study device) and the images acquired with conventional imaging methods, such as color fundus photography and/or angiography available through standard care. We will also use new software to measure ocular vasculature through motion contrast enhancement from the natural ocular blood flow. RTVue-XR with OCTA is a software modification to the cleared RTVue-XR device. The OCTA scan pattern is similar to a 3D cube scan of the cleared device. The populations to be studied for this study will be patients with age related macular degeneration, myopia, diabetic eye disease, optic nerve pathology and polypoidal choroidal vasculopathy. Added 12/31/2015- We will include patients with a possible ocular abnormality that affects the vasculature of the eye Updated - 05-02-2016 The device received FDA approval in 2/2016. Added 11/4/2016 - We will include patients with no clinically significant ocular abnormalities, as determined by the investigator(s), to serve as the control group for comparison. Software for data analysis may be made available in the near future and may be used to gather data on the images already taken and additional imaging on this device moving forward.