If you decide to participate, you will be asked to come to the research center for 3 study visits and 2 MRI visits.Visit 1 confirms that you are a good candidate for our study. It will include baseline labs, questionnaires, arterial tonometry [non-invasive technique to measure pressure in the arteries], a resting echocardiogram, and a Six-Minute Walk Test. You will be mailed drug A [either KNO3 or placebo] and will begin taking it. You will come back 6 weeks later to the research center for visit 2 which includes labs, resting echocardiogram, arterial tonometry, MRI scan, and a maximal effort bike test. You will then be mailed drug B [either KNO3 or placebo] and will begin taking it. You will come back 6 weeks later to the research center for the 3rd and final visit. This includes the same testing as visit 2.
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